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Proceedings Paper

Excellent antitumor effects for gastrointestinal cancers using photodynamic therapy with a novel glucose conjugated chlorin e6 (Conference Presentation)

Paper Abstract

Methods: G-chlorin e6 was synthesized with a core photosensitizer chlorin e6 conjugated to glucose. 1); The half maximal inhibitory concentration (IC50) was measured to compare the PDT effects of G-chlorin e6 and TS. 2); Flow cytometry was performed to examine the accumulation of G-chlorin e6 in cancer cells. We also compared the accumulation of G-chlorin e6 between normal immortalized esophageal epithelial cells and esophageal cancer cells. 3); In vivo using mice evaluation, the radio activated carbon 14 labeled G-chlorin e6 was manufactured for evaluation of the excretion from the body. 4); Antitumor effects of G-chlorin e6 PDT were analyzed in allograft tumor mouse models. Results: 1); PDT in vitro using G-chlorin e6 elicited 9, 000-34,000 times stronger antitumor effects than TS. 2); there was 70-190 times more G-chlorin e6 accumulated than TS by flow cytometry. G-chlorin e6 accumulated more selectively in esophageal cancer cells than in esophageal immortalized epithelial cells. 3); The excretion of G-chlorin e6 from plasma to bile juice was much faster than that of TS. 4); In an allograft model, PDT with G-chlorin e6 showed very strong antitumor effects and a 40% complete response (CR) rate.

Paper Details

Date Published: 14 August 2019
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Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110704K (14 August 2019); doi: 10.1117/12.2524148
Show Author Affiliations
Hirotada Nishie, Nagoya City Univ. Graduate School of Medical Sciences (Japan)
Hiroshi Ichikawa, Nagoya City Univ. Graduate School of Medical Sciences and Medical School (Japan)
Taketo Suzuki, Nagoya City Univ. Graduate School of Medical Sciences and Medical School (Japan)
Mamoru Tanaka, Nagoya City Univ. Graduate School of Medical Sciences and Medical School (Japan)
Akihiro Nomoto, Osaka Prefecture Univ. (Japan)
Shigenobu Yano, Nara Women's Univ. (Japan)
Hiromi Kataoka, Nagoya City Univ. Graduate School of Medical Sciences and Medical School (Japan)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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