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Proceedings Paper

Investigation of polyelectrolyte microcapsule aggregation in human blood
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Paper Abstract

One of the most effective ways of targeted drug delivery is the intravenous injection of carriers. However, to prevent undesirable side effects it is necessary to develop microencapsulation drug delivery systems that satisfy following requirements: biocompatibility, non-cytotoxity, biodegradability, colloidal stability in different medium solutions. In case of polymeric microcapsules, aggregation is a crucial and challenging question for biomedical applications that has not been studied well yet. We investigated polymeric microcapsules behavior in PBS, human plasma, and human blood in time. Aggregation degree was measured after 1, 10, 30, and 60 minutes of incubation in a stationary state. As a result, dynamics of capsules aggregation was shown for each medium.

Paper Details

Date Published: 3 June 2019
PDF: 7 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110651B (3 June 2019); doi: 10.1117/12.2523569
Show Author Affiliations
Roman A. Verkhovskii, Saratov State Univ. (Russian Federation)
Yuri Gagarin State Technical Univ. of Saratov (Russian Federation)
Anastasiia A. Kozlova, Saratov State Univ. (Russian Federation)
Alexey V. Ermakov, Saratov State Univ. (Russian Federation)
Ekaterina V. Lengert, Saratov State Univ. (Russian Federation)
Ghent Univ. (Belgium)
Daniil N. Bratashov, Saratov State Univ. (Russian Federation)
Moscow Institute of Physics and Technology (Russian Federation)


Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

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