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Proceedings Paper

Investigation of Ce6 accumulation and distribution in cell cultures of head and neck cancers
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Paper Abstract

Current paper presents the results of the chlorine e6 (Ce6) study on 2D and 3D models of FaDu cells culture. The 2D model or monolayer was used for investigation of Ce6 distribution within individual cells and their organelles. The 3D model or multicellular tumor spheroids were used for estimation of cells’ metabolic processes by the investigation of the Ce6 fluorescence distribution within spheroid's layers and Ce6 fluorescence lifetime. It was shown that 3D cell cultures and Сe6 allows estimating the cells’ metabolic processes better than in 2D monolayer cell cultures. Also, this model allows estimating the photodynamic effect depending on the proximity to the surface of different areas inside the heterogeneous 3D structure.

Paper Details

Date Published: 3 June 2019
PDF: 5 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110651V (3 June 2019); doi: 10.1117/12.2523465
Show Author Affiliations
Dina Farrakhova, Prokhorov General Physics Institute (Russian Federation)
Yulia Maklygina, Prokhorov General Physics Institute (Russian Federation)
Igor Romanishkin, Prokhorov General Physics Institute (Russian Federation)
Anastasia Ryabova, Prokhorov General Physics Institute (Russian Federation)
Ilya Yakavets, Ctr. de Recherche en Automatique de Nancy, Univ. de Lorraine, Institut de Cancérologie de Lorraine (France)
Marie Millard, Ctr. de Recherche en Automatique de Nancy, Univ. de Lorraine, Institut de Cancérologie de Lorraine (France)
Lina Bolotine, Ctr. de Recherche en Automatique de Nancy, Univ. de Lorraine, Institut de Cancérologie de Lorraine (France)
Anna Plyutinskaya, National Medical Research Radiological Ctr. (Russian Federation)
Tatyana Karmakova, National Medical Research Radiological Ctr. (Russian Federation)
Andrey Pankratov, National Medical Research Radiological Ctr. (Russian Federation)
Victor Loschenov, Prokhorov General Physics Institute (Russian Federation)
National Research Nuclear Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

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