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Proceedings Paper

When Na modulates Ca: nonlinear interplay between Na/Ca-exchanger and IP3-mediated Ca oscillations in astrocytes
Author(s): Darya V. Verveyko; Andrey Yu. Verisokin; Dmitry E. Postnov; Alexey R. Brazhe
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Paper Abstract

We present a composite model of astrocytic Ca2+ dynamics, which includes both IP3-mediated release from intracellular Ca2+ stores and bidirectional exchange through the plasma membrane, mediated by the Na+/Ca2+- exchanger (NCX). The NCX kinetic model is formulated in the Hodgkin/Huxley formalism, taking into account the glutamate transporter-mediated increase in Na+ during synaptic activity and Na+- and Ca2+-dependent regulation. We define main dynamic regimes and transitions in a point model, describing dynamics in an individual astrocyte segment. We demonstrate NCX-based modulation of store-mediated calcium oscillations (amplitude, frequency and amplitude-frequency), analyze and compare calcium dynamics in models with and without allosteric regulation of NCX by intracellular ions.

Paper Details

Date Published: 3 June 2019
PDF: 7 pages
Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 110670J (3 June 2019); doi: 10.1117/12.2523315
Show Author Affiliations
Darya V. Verveyko, Kursk State Univ. (Russian Federation)
Andrey Yu. Verisokin, Kursk State Univ. (Russian Federation)
Dmitry E. Postnov, Saratov State Univ. (Russian Federation)
Alexey R. Brazhe, M.V. Lomonosov Moscow State Univ. (Russian Federation)
Institute of Bio-organic Chemistry (Russian Federation)

Published in SPIE Proceedings Vol. 11067:
Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions
Dmitry Engelevich Postnov, Editor(s)

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