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Proceedings Paper

OCT lymphangiography based on speckle statistics evaluation
Author(s): Lev A. Matveev; Valentin Demidov; Marina A. Sirotkina; Dmitry A. Karashtin; Alexander A. Moiseev; Ivan Popov; Alexander A. Sovetsky; Alexander L. Matveyev; Olga Demidova; Grigory V. Gelikonov; Costel Flueraru; Elena V. Zagaynova; Natalia D. Gladkova; Vladimir Y. Zaitsev; I. Alex Vitkin
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Paper Abstract

We present an optical coherence tomography (OCT) lymphangiography visualization approach based on analysis of speckle statistics. For in-vivo experimentation, normal and tumor tissues are examined in mouse dorsal skin window chamber model. In order to evaluate the speckle statistics, OCT datasets are acquired in 3 spatial and 1 temporal dimensions to be divided then into smaller volumes of interests. In temporal dimension, repeated same-location scanning is performed for simultaneous blood vessel detection through speckle variance processing. Speckle statistics in each volume of interest are tested for similarity to known distributions corresponding either to noise or to tissue. We show that lymphatic vessels could be detected using a specific parameter range of speckle statistics as a filter, to separate the surrounding tissues and blood vessels. The proposed approach does not require numerous post-processing steps that are often used in lymphatic detection methods that are based on low signal amplitude regions (e.g., OCT signal attenuation compensation, inversion, amplitude thresholding etc.). Instead, we use a fast 2-step filtering procedure to reveal lymphatic vessels in imaged tissues.

Paper Details

Date Published: 3 June 2019
PDF: 5 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106502 (3 June 2019); doi: 10.1117/12.2523291
Show Author Affiliations
Lev A. Matveev, Institute of Applied Physics (Russian Federation)
Valentin Demidov, Univ. of Toronto (Canada)
Marina A. Sirotkina, Privolzhsky Research Medical Univ. (Russian Federation)
Dmitry A. Karashtin, Institute of Applied Physics (Russian Federation)
Alexander A. Moiseev, Institute of Applied Physics (Russian Federation)
Ivan Popov, Univ. of Toronto (Canada)
Alexander A. Sovetsky, Institute of Applied Physics (Russian Federation)
Alexander L. Matveyev, Institute of Applied Physics (Russian Federation)
Olga Demidova, Seneca College (Canada)
Grigory V. Gelikonov, Institute of Applied Physics (Russian Federation)
Costel Flueraru, National Research Council Canada (Canada)
Elena V. Zagaynova, Privolzhsky Research Medical Univ. (Russian Federation)
Natalia D. Gladkova, Privolzhsky Research Medical Univ. (Russian Federation)
Vladimir Y. Zaitsev, Institute of Applied Physics (Russian Federation)
I. Alex Vitkin, Univ. of Toronto (Canada)
Univ. Health Network (Canada)


Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

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