Share Email Print
cover

Proceedings Paper

Fluorescence spectroscopy approach for blood influence compensation
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

At present, fluorescence spectroscopy (FS) and diffuse reflectance spectroscopy (DRS) are widespread methods highly used in medical practice. The combined application of these methods is a promising tool to improve the predictive force of classifiers for tissue type recognition as well as to compensate the attenuation of the fluorescence radiation by blood for the accurate evaluation of the biomarkers content in living tissue. Several techniques are known to normalize the resulting fluorescence spectrum in order to exclude the attenuation effect. In this study, an approach based on the dividing of the experimentally obtained FS spectrum by DRS spectrum has been applied for experiments with occlusion test. The implemented multimodal approach for the in vivo optical measurements in combination with occlusion test for minimisation of blood influence has shown good repeatability of obtained experimental fluorescence spectra. The results are of particular interest for the further development of methods for compensating the influence of chromophores in optical spectroscopy.

Paper Details

Date Published: 3 June 2019
PDF: 5 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110650R (3 June 2019); doi: 10.1117/12.2522794
Show Author Affiliations
Valery Shupletsov, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Viktor Dremin, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Evgeny Zherebtsov, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Univ. of Oulu (Finland)
Mikhail Mezentsev, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Igor Kozlov, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Elena Potapova, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Andrey Dunaev, Orel State Univ. named after I.S. Turgenev (Russian Federation)


Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray