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Proceedings Paper

Photodynamic therapy with a novel zinc phthalocyanine: an innovative approach to hepatocellular carcinoma treatment
Author(s): Racheal O. Ogbodu; Bianca Nitzsche; Michael Höpfner
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Paper Abstract

The photodynamic activity (PDT) of Tetra triethyleneoxysulfonyl zinc phthalocyanine (ZnPc) was studied on HepG2 and Huh-7 cells a typical example of hepatocellular carcinoma (HCC). HCC cells showed a dose dependent uptake of ZnPc. Photo-activation of ZnPc (0.5-5 µM) in HCC cells revealed strong PDT effects, leading to a dose-dependent decrease of cancer cells without any sign of re-proliferation and a dose-dependent increase in caspase-3-activity. By contrast, non-photoactivated ZnPc did not induce any cytotoxicity. The formation of ROS and free radical detected in the cytoplasm/nucleus of HCC cells and the expression of apoptotic proteins confirm the apoptotic mode of cell death.

Paper Details

Date Published: 7 August 2019
PDF: 1 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070AG (7 August 2019); doi: 10.1117/12.2522169
Show Author Affiliations
Racheal O. Ogbodu, Charité Universitätmedizin Berlin (Germany)
Bianca Nitzsche, Charité Universitätmedizin Berlin (Germany)
Michael Höpfner, Charité Universitätsmedizin Berlin (Germany)

Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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