Normal and pathological tissues are different in their elastic properties. Thus, elastic characteristics of tissues can serve as an additional diagnostic marker to distinguish altered tissues. A number of studies have demonstrated advantages of using optical coherent tomography in clinical practice and research. Here we report the application of optical coherence elastography (OCE) for studying elastic properties of murine breast cancer 4T1. It is known that 4T1 model is convenient for in vivo tumor imaging and is highly relevant to studies of tumor process. In this study the therapy was performed with a cytostatic chemotherapeutic drug cisplatin. We developed the protocol of compressional OCT elastography for long-term in vivo monitoring of tumor response to anti-tumor therapy. The ear tumor model was chosen as optimal for this task. Histological analysis demonstrated good agreement with OCE-based stiffness-mapping results.

Date Published: 3 June 2019
PDF: 8 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106506 (3 June 2019); doi: 10.1117/12.2521571

Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)