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Proceedings Paper

SERS detection of some drugs using aluminum hydroxide with embedded copper nanoparticles
Author(s): Natalia E. Markina; Ilya A. Gorbachev; Elena V. Badaeva; Andrey M. Zakharevich; Alexey V. Markin
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Paper Abstract

The work is dedicated to fabrication and study of SERS-active nanocomposites based on aluminum hydroxide with incorporated copper nanoparticles (CuNP; 10±2 nm). The initial CuNP and the final composite were characterized using SEM, EDX, STM, and absorbance spectroscopy in UV-visible range. The application of incorporation enabled to improve temporal stability of SERS-activity of the CuNP against oxidation to around 80 times compare to colloidal CuNP; the composite is SERS-active for more than 8 days. The value of Raman enhancement was found around 8×106 that is comparable with the values for silver and gold based SERS substrates. The applicability of the final composite for chemical analysis was demonstrated by SERS detection of some drugs, such as antitumor (methotrexate) and antibacterial drugs (lincomycin, sulfadimethoxine, ceftriaxone). The analytes were detected at concentrations which have to be detected at physiological conditions in urine (50‒100 μg/mL) after medical treatment.

Paper Details

Date Published: 3 June 2019
PDF: 6 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110651A (3 June 2019); doi: 10.1117/12.2521210
Show Author Affiliations
Natalia E. Markina, Saratov State Univ. (Russian Federation)
Ilya A. Gorbachev, Saratov State Univ. (Russian Federation)
Elena V. Badaeva, Saratov State Univ. (Russian Federation)
Andrey M. Zakharevich, Saratov State Univ. (Russian Federation)
Alexey V. Markin, Saratov State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

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