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Proceedings Paper

The personalised diagnosis program of functional maladjustment of the human organism
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Paper Abstract

A process of health-saving accompaniment individualization implies constant monitoring of the functional state. There is a universal method of instrumental evaluation and prediction of the human adaptive state, considering its individual, genetically determined structural and functional characteristics. It is a method of LGNRO assessment. LGNRO is for a level of general nonspecific reactivity of an organism, qualitatively and quantitatively characterizing a level of individual sensitivity and reactivity to various exogenous effects. The biometric analysis of the organism’s nociceptive characteristics has revealed the general biological character of the normal distribution of the thermal sensitivity threshold (TST) in human populations and laboratory animals. The possibility of a rapid assessment of LGNRO by means of TST is justified. Morphofunctional characteristics of individual brain structures and their role in the formation of LGNRO have been determined. The genetic determinancy of phenotypic manifestations of LGNRO has been proved. Based on the results of experimental studies, an algorithm and a corresponding computer program have been developed that provides system-specific personalized monitoring of human health status in real time.

Paper Details

Date Published: 3 June 2019
PDF: 11 pages
Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 110670D (3 June 2019); doi: 10.1117/12.2521078
Show Author Affiliations
Alexander B. Mulik, Institute of Toxicology Federal Medical-Biological Academy (Russian Federation)
Margarita V. Postnova, Volgograd State Univ. (Russian Federation)
Viktoriya O. Samarskaya, Volgograd State Univ. (Russian Federation)
Irina V. Ulesikova, Kirov State Medical Academy (Russian Federation)
Yulia A. Shatyr, Volgograd State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11067:
Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions
Dmitry Engelevich Postnov, Editor(s)

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