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Proceedings Paper

Photodynamic diagnostics for stomach cancer detection in stress modeled lesions in vivo
Author(s): Ilana Agranovich; Alexander Khorovodov; Aysel Mamedova; Anastasia Shnitenkova; Veronika Shimanova; Nikita Navolokin; Tatiana Vashenko; Matvey Kanevsky; Anna Galitskaya; Svetlana Konnova; Ekaterina Borisova; Oxana Semyachkina-Glushkovskaya
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Paper Abstract

Gastric cancer is the main cause of death among oncological diseases of the gastrointestinal tract, which is associated with the difficulty of early diagnosis of this disease. This study aims to develop a new method for diagnosing gastric cancer using the delta-aminolevulinic acid / protoporphyrin IX photosensitizer (5-ALA / PpIX). The experiments were performed on white rats of average weight 250 grams. The animals were divided into 2 groups: control and experimental (stress + diet, including nitrites and carcinogenic amines) ones. The results of the studies, averaged for each type of tissue, clearly show significant differences between normal, precancerous and malignant changes in the stomach tissues of rats on the background of application of photodynamic diagnostics. The fluorescence from malignant neoplasms in the organ was maximal at 635 nm, which corresponds to the maximum emission of protoporphyrin due to the high accumulation of this photosensitizer in the affected tissues. The most important result of the study was the detection of precancerous changes (atrophic gastritis, confirmed by histological methods), using photodynamic diagnostics with photosensitizer 5-ALA / PpIX. Intensity of fluorescence in case of precancerous changes occupied an intermediate value between that in normal and in malignant mucosa of the stomach.

Paper Details

Date Published: 3 June 2019
PDF: 6 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110650B (3 June 2019); doi: 10.1117/12.2520148
Show Author Affiliations
Ilana Agranovich, Saratov State Univ. (Russian Federation)
Alexander Khorovodov, Saratov State Univ. (Russian Federation)
Aysel Mamedova, Saratov State Univ. (Russian Federation)
Anastasia Shnitenkova, Saratov State Univ. (Russian Federation)
Veronika Shimanova, Saratov State Univ. (Russian Federation)
Nikita Navolokin, Saratov State Medical Univ. (Russian Federation)
Tatiana Vashenko, Saratov State Univ. (Russian Federation)
Matvey Kanevsky, Saratov State Univ. (Russian Federation)
Anna Galitskaya, Saratov State Univ. (Russian Federation)
Svetlana Konnova, Saratov State Univ. (Russian Federation)
Ekaterina Borisova, Saratov State Univ. (Russian Federation)
Institute of Electronics (Bulgaria)
Oxana Semyachkina-Glushkovskaya, Saratov State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

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