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Proceedings Paper

Integrated microfluidic probes for cell manipulation and analysis
Author(s): Ayoola Brimmo; Ayoub Glia; Pavithra Sukumar; Roaa Alnemari; Anoop Menachery; Muhammedin Deliorman; Mohammad A. Qasaimeh
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Paper Abstract

The microfluidic probe (MFP) is a non-contact technology that applies the concept of hydrodynamic flow confinement within a small gap to eliminate the need for closed conduits, and thus overcomes the conventional microfluidic “closed system” limitations. It is an open-space microfluidic concept, where the fluidic delivery mechanism is physically decoupled from the target surface to be processed such as tissue slices or cell culture in Petri dishes. Typically, MFPs are manufactured using complex photolithography-based microfabrication procedures that limits innovation in MFPs’ design and integration. Recently, we showed that 3D printing can be utilized for rapid microfabrication of MFPs, where MFPs can be manufactured with built-in components such as reservoirs, fluidic connectors, and interfaces to the XYZ probe holder. 3D printing brings flexibility in MFP design, where different configurations and aperture arrangements can be considered. Currently, we are developing advanced MFPs that are integrated with other technologies and targeting applications in dielectrophoretic-based cell separation, immuno-based cell capture for isolating circulating tumor cells from blood samples, and efficient and selective single cell electroporation. In this invited paper, we highlight several MFP technologies we are developing.

Paper Details

Date Published: 4 March 2019
PDF: 6 pages
Proc. SPIE 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII, 108750R (4 March 2019); doi: 10.1117/12.2515270
Show Author Affiliations
Ayoola Brimmo, New York Univ. Abu Dhabi (United Arab Emirates)
New York Univ. Tandon School of Engineering (United States)
Ayoub Glia, New York Univ. Abu Dhabi (United Arab Emirates)
New York Univ. Tandon School of Engineering (United States)
Pavithra Sukumar, New York Univ. Abu Dhabi (United Arab Emirates)
Roaa Alnemari, New York Univ. Abu Dhabi (United Arab Emirates)
Anoop Menachery, New York Univ. Abu Dhabi (United Arab Emirates)
Muhammedin Deliorman, New York Univ. Abu Dhabi (United Arab Emirates)
Mohammad A. Qasaimeh, New York Univ. Abu Dhabi (United Arab Emirates)
New York Univ. Tandon School of Engineering (United States)


Published in SPIE Proceedings Vol. 10875:
Microfluidics, BioMEMS, and Medical Microsystems XVII
Bonnie L. Gray; Holger Becker, Editor(s)

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