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Proceedings Paper

Ultrasound-guided breast biopsy of ultrasound occult lesions using multimodality image co-registration and tissue displacement tracking
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Paper Abstract

Fusion-based ultrasound (US)-guided biopsy in a breast is challenging due to the high deformability of the tissue combined with the fact that the breast is usually differently deformed in CT, MR, and US acquisition which makes registration difficult. With this phantom study, we demonstrate the feasibility of a fusion-based ultrasound-guided method for breast biopsy. 3D US and 3D CT data were acquired using dedicated imaging setups of a breast phantom freely hanging in prone position with lesions. The 3D breast CT set up was provided by Koning (Koning Corp., West Henrietta, NY). For US imaging, a dedicated breast scanning set up was developed consisting of a cone-shaped revolving water tank with a 152- mm-sized US transducer mounted in its wall and an aperture for needle insertion. With this setup, volumetric breast US data (0.5×0.5×0.5 mm3 voxel size) can be collected and reconstructed within 3 minutes. The position of the lesion as detected with breast CT was localized in the US data by rigid registration. After lesion localization, the tank rotates the transducer until the lesion is in the US plane. Since the lesion was visible on ultrasound, the performance of the registration was validated. To facilitate guided biopsy, the lesion motion, induced by needle insertion, is estimated using cross-correlation-based speckle tracking and the tracked lesion visualized in the US image at an update frequency of 10 Hz. Thus, in conclusion a fusion-based ultrasound-guided method was introduced which enables ultrasound-guided biopsy in breast that is applicable also for ultrasound occult lesions.

Paper Details

Date Published: 15 March 2019
PDF: 9 pages
Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 109550W (15 March 2019); doi: 10.1117/12.2513630
Show Author Affiliations
Anton Nikolaev, Radboud Univ. Medical Ctr. (Netherlands)
Hendrik H. G. Hansen, Radboud Univ. Medical Ctr. (Netherlands)
Leon de Jong, Radboud Univ. Medical Ctr. (Netherlands)
Ritse Mann, Radboud Univ. Medical Ctr. (Netherlands)
Eleonora Tagliabue, Univ. degli Studi di Verona (Italy)
Bogdan Maris, Univ. degli Studi di Verona (Italy)
Vincent Groenhuis, Univ. of Twente (Netherlands)
Françoise Siepel, Univ. of Twente (Netherlands)
Marco Caballo, Radboud Univ. Medical Ctr. (Netherlands)
Ioannis Sechopoulos, Radboud Univ. Medical Ctr. (Netherlands)
LRCB (Netherlands)
Chris L. de Korte, Radboud Univ. Medical Ctr. (Netherlands)
Univ. of Twente (Netherlands)

Published in SPIE Proceedings Vol. 10955:
Medical Imaging 2019: Ultrasonic Imaging and Tomography
Brett C. Byram; Nicole V. Ruiter, Editor(s)

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