Vascular targeted photodynamic therapy (V-PDT) has shown satisfied efficiency in treating vascular-related diseases including age-related macular degeneration, port-wine stains (PWS), and prostate cancer. Its efficacy is a complex function of photosensitizer (PS) uptake, oxygen concentration, PS-activating light dose and tissue optical properties. In order to non -invasively monitor PS distribution and photobleaching, blood vessel contraction and blood flow velocity for V-PDT response, a multimode optical imaging (MOI) system was developed to capture PS fluorescence image, narrow band image and laser speckle image, respectively. V-PDT in vivo studies were performed, which suggests that our MOI system is capable of monitoring dynamic response during V-PDT treatment.

Date Published: 7 March 2019
PDF: 6 pages
Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087906 (7 March 2019); doi: 10.1117/12.2513578

Published in SPIE Proceedings Vol. 10879:
Biophotonics and Immune Responses XIV
Wei R. Chen, Editor(s)