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Proceedings Paper

Monitoring vascular targeted PDT response with multimode optical imaging
Author(s): Yi Shen; Fuqiang Liang; Yanhui Niu; Huiyun Lin; Ying Gu; Brian C. Wilson; Buhong Li
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Paper Abstract

Vascular targeted photodynamic therapy (V-PDT) has shown satisfied efficiency in treating vascular-related diseases including age-related macular degeneration, port-wine stains (PWS), and prostate cancer. Its efficacy is a complex function of photosensitizer (PS) uptake, oxygen concentration, PS-activating light dose and tissue optical properties. In order to non -invasively monitor PS distribution and photobleaching, blood vessel contraction and blood flow velocity for V-PDT response, a multimode optical imaging (MOI) system was developed to capture PS fluorescence image, narrow band image and laser speckle image, respectively. V-PDT in vivo studies were performed, which suggests that our MOI system is capable of monitoring dynamic response during V-PDT treatment.

Paper Details

Date Published: 7 March 2019
PDF: 6 pages
Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087906 (7 March 2019); doi: 10.1117/12.2513578
Show Author Affiliations
Yi Shen, Fujian Normal Univ. (China)
Fuqiang Liang, Fujian Normal Univ. (China)
Yanhui Niu, Fujian Normal Univ. (China)
Huiyun Lin, Fujian Normal Univ. (China)
Ying Gu, Chinese PLA General Hospital (China)
Brian C. Wilson, Univ. of Toronto, Univ. Health Network (Canada)
Buhong Li, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 10879:
Biophotonics and Immune Responses XIV
Wei R. Chen, Editor(s)

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