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Proceedings Paper

Electroacoustic tomography system with nanosecond electric pulse excitation source
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Paper Abstract

The new technique for the imaging guidance to real-time monitoring of electroporation-based medical interventions could be based on the electroacoustic tomography (EAT), where the electric field applied for the electroporation process leads to induced acoustic signals based on the flow of electrical current inside the target conductive tissue. A microsecond to nanosecond electric-pulse (πœ‡π‘  βˆ’ 𝑛𝑠𝐸𝑃) excitation source is an essential part of this new imaging guided to real-time monitoring electroporation process. This paper presents the design, configuration, and measurement of a compact, low-cost high voltage MOSFET-based pulsed excitation source and the simple structure of the EAT system with the single channel ultrasonic transducer to acquire acoustic signals and complemented by experimentation of its function based on agar-conductive phantom studies. The high-voltage pulsed excitation source has variable pulse widths ranging from 100 𝑛𝑠 π‘‘π‘œ 10 πœ‡π‘  electric pulse with a variable pulse potential magnitude of up to 1200 Volts (V). The high-voltage πœ‡π‘  βˆ’ 𝑛𝑠𝐸𝑃 is powered from a variable input source of 11.3 to 16 V in direct current (DC) and a power controller using a 0 V to 5 V in DC power line so that it is able to provide 0 to full output in potential magnitude. The high-intensity, ultra-short pulsed electric field is then connected to two electrodes separated by a distance (d) where 𝑑 = 1500πœ‡π‘š π‘‘π‘œ 3400 πœ‡ mounted into the conductive media. An unfocused ultrasound transducer with central frequency of 500 kHz is used to acquire real-time acoustic signals. Various conductive media, including two agar-based phantoms with conductivity of 1 πœ‡π‘†/π‘π‘š , 34 π‘šπ‘†/π‘π‘š were studied using this pulsed excitation source to induce corresponding acoustic signals. Results indicate feasibility of the enhancing the EAT system that used up to 8 kV/cm, πœ‡π‘  π‘‘π‘œ 𝑛𝑠 pulsed excitation source used in the electroporation-based clinical processes enhancing the EAT system as an imaging guidance to real-time, in-situ monitoring for the electroporation-based techniques.

Paper Details

Date Published: 15 March 2019
PDF: 6 pages
Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 109551B (15 March 2019); doi: 10.1117/12.2513051
Show Author Affiliations
Ali Zarafshani, The Univ. of Oklahoma (United States)
John Merrill, The Univ. of Oklahoma (United States)
Siqi Wang, The Univ. of Oklahoma (United States)
Bin Zheng, The Univ. of Oklahoma (United States)
Liangzhong Xiang, The Univ. of Oklahoma (United States)

Published in SPIE Proceedings Vol. 10955:
Medical Imaging 2019: Ultrasonic Imaging and Tomography
Brett C. Byram; Nicole V. Ruiter, Editor(s)

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