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Proceedings Paper

Quantitative phase microscopy for label-free evaluation of intestinal inflammation
Author(s): Björn Kemper; Arne Bokemeyer; Steffi Ketelhut; Philipp Lenz; Dominik Bettenworth
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Paper Abstract

In overview, for the example of digital holographic microscopy (DHM), we present quantitative phase imaging (QPI)- based characterization of inflammation in colonic tissue sections. Tissue density alterations are determined by the refractive index retrieval from quantitative DHM phase images. We show that the average tissue refractive index represents a marker that allows to distinguish between different layers of the intestinal wall and that the revealed tissue refractive index data correlated well with the severity of inflammation. In summary, QPI provides biophysical parameters for the quantification of inflammation in intestinal tissues and paves the way for future applications in terms of ‘‘digital pathology’’.

Paper Details

Date Published: 4 March 2019
PDF: 5 pages
Proc. SPIE 10887, Quantitative Phase Imaging V, 1088710 (4 March 2019); doi: 10.1117/12.2511947
Show Author Affiliations
Björn Kemper, Univ. of Muenster (Germany)
Arne Bokemeyer, Univ. Hospital of Muenster (Germany)
Steffi Ketelhut, Univ. of Muenster (Germany)
Philipp Lenz, Univ. Hospital of Muenster (Germany)
Dominik Bettenworth, Univ. Hospital of Muenster (Germany)


Published in SPIE Proceedings Vol. 10887:
Quantitative Phase Imaging V
Gabriel Popescu; YongKeun Park, Editor(s)

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