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Proceedings Paper

High spatial resolution x-ray luminescence computed tomography and x-ray fluorescence computed tomography
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Paper Abstract

X-ray luminescence computed tomography (XLCT) and X-ray fluorescence computed tomography (XFCT) are two emerging technologies in X-ray imaging. In these modalities, images are formed through detection of secondary emissions (light in XLCT, or secondary X-rays in XFCT) following X-ray excitations. XLCT and XFCT enable us to leverage the widely used X-ray imaging for simultaneous in vivo molecular and functional imaging. Depending on the geometry of the excitation X-ray beam (pencil-, fan-, and cone-beam or coded apertures), optimal tradeoff between imaging efficiency and spatial resolution can be achieved. The novel imaging principles of XLCT/XFCT make it possible to achieve a spatial resolution comparable to that of anatomical X-ray imaging. Here, we summarize our studies in this area in the past decade and discuss their prospects.

Paper Details

Date Published: 7 March 2019
PDF: 11 pages
Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 1086218 (7 March 2019); doi: 10.1117/12.2511875
Show Author Affiliations
Xianjin Dai, Stanford Univ. School of Medicine (United States)
Kathyayini Sivasubramanian, Stanford Univ. School of Medicine (United States)
Lei Xing, Stanford Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 10862:
Molecular-Guided Surgery: Molecules, Devices, and Applications V
Brian W. Pogue; Sylvain Gioux, Editor(s)

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