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Proceedings Paper

Evaluation of silver sulfide nanoparticles as a contrast agent for spectral photon-counting digital mammography: a phantom study
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Paper Abstract

The objective of our study was to evaluate the feasibility of using silver sulfide nanoparticles (Ag2S-NP) as a contrast agent for photon-counting mammography. The efficacies of Ag2S-NP and iodine contrast were evaluated using a contrastembedded gradient phantom. The phantom was constructed using tissue-equivalent materials and varied continuously in composition from 100% glandular tissue to 100% adipose tissue. Each contrast agent was prepared at eight different concentrations: 1, 2, 5, 10, 15, 20, 25, and 30 mg/mL. Tubes of contrast agent were inserted into holes bored through the phantom in the direction of varying glandularity. Various images of the phantom were acquired by altering the acquisition parameters (kV, mAs, and high bin fraction). A range of beam energies from 26 kV to 40 kV was tested in this study. Our results demonstrate that for a given contrast agent, the contrast-to-noise ratio (CNR) is linearly proportional to concentration, and its magnitude is dependent on the kV of the spectrum. At mammographic energies, the Ag2S-NP contrast increases with increasing kV and increasing solution concentration. Comparatively, the iodine signal becomes detectable only when the kV of the image is above iodine’s K-edge (33.2 keV). This indicates that the optimal energy for imaging iodine may exceed the clinical mammographic energy range. In summary, we have demonstrated the feasibility of using Ag2S-NP as a contrast agent for breast imaging. Preliminary results from spectral photon-counting mammography indicate that Ag2S-NP contrast has a significantly higher signal than iodine, especially when imaging at lower energies.

Paper Details

Date Published: 1 March 2019
PDF: 9 pages
Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109481J (1 March 2019); doi: 10.1117/12.2511757
Show Author Affiliations
Kristen C. Lau, Univ. of Pennsylvania (United States)
Jessica C. Hsu, Univ. of Pennsylvania (United States)
Björn Cederström, Philips Digital Mammography Sweden AB (Sweden)
David P. Cormode, Univ. of Pennsylvania (United States)
Andrew D. A. Maidment, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 10948:
Medical Imaging 2019: Physics of Medical Imaging
Taly Gilat Schmidt; Guang-Hong Chen; Hilde Bosmans, Editor(s)

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