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Proceedings Paper

Tomosynthesis method for depth resolution of beta emitters
Author(s): Thomy Mertzanidou; Nick Calvert; David Tuch; Danail Stoyanov; Simon Arridge
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Paper Abstract

The motivation of this study derives from the need for tumour margin estimation after surgical excision. Conventional beta autoradiography of beta emitters can be used to image tissue sections providing high spatial resolution compared to in-vivo molecular imaging. However, it requires sectioning of the specimen and it provides a 2D image of the tissue. Imaging of the 3D tissue sample can be achieved either by imaging sequential 2D sections, which is time-consuming and laborious, or by using a specialised detector for imaging that records the particles’ direction, in addition to their position, when they hit the detector. In this work we investigate whether a novel beta-tomosynthesis approach can be used for depth resolution of beta emitters. The technique involves acquiring multiple 2D images of the intact tissue sample while the detector rotates around the sample. The images are then combined and used to reconstruct the 3D position of the sources from a limited angle of conventional 2D autoradiography images. We present the results from Geant4 forward simulations and the reconstructed images from a breast tissue sample containing a Fluorine-18 positron emission source. The experiments show that the proposed method can provide depth resolution under certain conditions, indicating that there is potential for its use as a 3D molecular imaging technique of surgical samples in the future.

Paper Details

Date Published: 15 March 2019
PDF: 7 pages
Proc. SPIE 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging, 109531G (15 March 2019); doi: 10.1117/12.2511753
Show Author Affiliations
Thomy Mertzanidou, Univ. College London (United Kingdom)
Nick Calvert, Univ. College London (United Kingdom)
David Tuch, Lightpoint Medical, Ltd. (United Kingdom)
Danail Stoyanov, Univ. College London (United Kingdom)
Simon Arridge, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 10953:
Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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