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Proceedings Paper

Description of brain volumetric changes in Alzheimer disease using region-based morphometry
Author(s): Sebastian Maglioni; Diana L. Giraldo; Juan Duarte; Nelson Velasco; Eduardo Romero
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Paper Abstract

This paper aims to automatically describe changes occurring in brain regions of patients from the OASIS database as follows: 66 control patients (CN), 20 patients diagnosed with mild Alzheimer’s disease (AD) and 50 with mild cognitive impairment (MCI). A regional-based morphometry method is proposed to explore the location of anatomical differences functionally connected between AD, MCI and CN subjects. A first step provides a set of regions with statistically significant volume differences which are then challenged by a classification task, providing a second set of regions that demonstrate better performance when separating the groups. Afterward, connectivity between these regions is analyzed to establish how functionally connected these regions are. Results demonstrate the disease follows functional patterns rather than anatomical ones.

Paper Details

Date Published: 21 December 2018
PDF: 11 pages
Proc. SPIE 10975, 14th International Symposium on Medical Information Processing and Analysis, 109750R (21 December 2018); doi: 10.1117/12.2511533
Show Author Affiliations
Sebastian Maglioni, Univ. Nacional de Colombia (Colombia)
Diana L. Giraldo, Univ. Nacional de Colombia (Colombia)
Univ. of Antwerp (Belgium)
Juan Duarte, Univ. Nacional de Colombia (Colombia)
Nelson Velasco, Univ. Nacional de Colombia (Colombia)
Univ. Militar Nueva Granada (Colombia)
Eduardo Romero , Univ. Nacional de Colombia (Colombia)

Published in SPIE Proceedings Vol. 10975:
14th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Jorge Brieva, Editor(s)

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