At present, nanobiomedicine is one of the most actively and successfully developing areas of nanotechnology. One of the important areas of modern biomedicine is the creation of a new generation of implants that are not rejected by the human immune system. Carbon nanotubes are widely used to solve this problem. 3D wireframe composite nanomaterials are created on the basis of carbon nanotubes under the action of an electric field of pulsed or continuous laser radiation. The presence of such framework creates conditions for the self-organization of the cellular material for biological tissues. Promising biomaterials for the creation of bulk nanocomposites are albumin and collagen. Albumin is a protein-transporter in the blood for many substances, and collagen is the basis of the intercellular substance of the connective tissue of the tendons, bone, cartilage, and skin. Both proteins belong to the group of natural biopolymers used in tissue engineering for the purpose of regenerating neurons. In this work, we constructed an atomistic model of a mixture of single-walled carbon nanotubes in a protein matrix based on albumin and collagen, taking into account the curvature, twisting, overlapping, and other topological features of carbon nanotubes. Conditions for the formation of an energy-stable nanocarbon framework with protein filling, promising for use in cell engineering, are revealed using the methods of atomistic and coarsegrained molecular dynamic modeling.

Date Published: 7 March 2019
PDF: 6 pages
Proc. SPIE 10893, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI, 108930W (7 March 2019); doi: 10.1117/12.2511078

Published in SPIE Proceedings Vol. 10893:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI
Samuel Achilefu; Ramesh Raghavachari, Editor(s)