Share Email Print
cover

Proceedings Paper

Subcellular localization of gold nanorods in cancerous cells
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Gold nanorods (GNRs) have the potential for cancer treatment as tumor-targeting photosensitizers due to their strong absorption of near-infrared light. The purpose of this project was to study the subcellular localization of GNRs in cancerous to optimize cancer treatment using irradiation at appropriate wavelength. Subcellular localization of gold nanorods has been shown to have a significant impact on the retention or exclusion of GNRs within the cells as well as cell viability and morphology. GNRs were functionalized with a fluorescent dye, incubated with cells, and then imaged using a fluorescent microscope. Our results demonstrated the localization of GNRs in cancer cell mitochondria and lysosomes, which corroborates the findings of other studies. Further studies will determine the functions of the subcellular GNRs under irradiation of laser of appropriate wavelengths. Our research could lead to a targeted, effective nanotechnology based laser immunotherapy.

Paper Details

Date Published: 7 March 2019
PDF: 5 pages
Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087917 (7 March 2019); doi: 10.1117/12.2510979
Show Author Affiliations
Sana Mesiya, Univ. of Central Oklahoma (United States)
Austin Doughty, Univ. of Central Oklahoma (United States)
Benqing Zhou, Univ. of Central Oklahoma (United States)
Elivia Layton, Univ. of Central Oklahoma (United States)
Feifan Zhou, Univ. of Central Oklahoma (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)


Published in SPIE Proceedings Vol. 10879:
Biophotonics and Immune Responses XIV
Wei R. Chen, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray