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Proceedings Paper

Characterization of collagen formation surrounding osteocytes using second and third harmonic generation
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Paper Abstract

More than 54 million Americans have or are at high risk of developing a metabolic bone disease; disorders of bone strength that leave individuals with fragile bones and disabilities. The gold standard to evaluate these diseases is dual energy x-ray absorptiometry, but this only measures mineral content. These diseases, however, impact collagen and mineral integrity which impede the bone’s ability to store hormones, proteoglycans, and glycoproteins imperative to homeostasis. We have established a second harmonic generation (SHG) polarimetric assay that describes bone collagen organization. To further our analysis, we propose multimodal optical evaluation of bone quality with third harmonic generation (THG) to measure osteocyte dendritic processes. This method of analysis could be used to evaluate the disease state of bone and response to therapy.

Paper Details

Date Published: 27 February 2019
PDF: 8 pages
Proc. SPIE 10871, Multimodal Biomedical Imaging XIV, 108710W (27 February 2019); doi: 10.1117/12.2510814
Show Author Affiliations
Emily G. Pendleton, The Univ. of Georgia (United States)
Kayvan F. Tehrani, The Univ. of Georgia (United States)
Ruth P. Barrow, The Univ. of Georgia (United States)
Luke J. Mortensen, The Univ. of Georgia (United States)


Published in SPIE Proceedings Vol. 10871:
Multimodal Biomedical Imaging XIV
Fred S. Azar; Xavier Intes; Qianqian Fang, Editor(s)

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