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Proceedings Paper

An adaptive-coherence light source for hyperspectral, topographic, and flow-contrast imaging
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Paper Abstract

Colorectal cancer accounts for an estimated 8% of cancer deaths in the United States with a five-year survival rate of 55-75%. The early detection and removal of precancerous lesions is critical for reducing mortality, but subtle neoplastic growths, such as non-polypoid lesions, often go undetected during routine colonoscopy. Current approaches to flat or depressed lesion detection are ineffective due to the poor contrast of subtle features in white light endoscopy. Towards improving colorectal lesion contrast, we present an endoscopic light source with custom laser channels for multimodal color, topographic, and speckle contrast flow imaging. Three red-green-blue laser units, paired with laser speckle reducers, are coupled into endoscopic fiber optic light guides in a benchtop endoscope. Tissue phantom topography is reconstructed using alternating illumination of the laser units and a photometric stereo endoscopy algorithm. The contrast of flow regions is enhanced in an optical flow phantom using laser speckle contrast imaging. Further, the system retains the ability to offer white light and narrow band illumination modes with improved power efficiency, a reduced size, and longer lifetimes compared to conventional endoscopic arc lamp sources. This novel endoscopic light source design shows promise for increasing the detection of subtle lesions in routine colonoscopy screening.

Paper Details

Date Published: 27 February 2019
PDF: 7 pages
Proc. SPIE 10871, Multimodal Biomedical Imaging XIV, 108710Y (27 February 2019); doi: 10.1117/12.2510632
Show Author Affiliations
Taylor L. Bobrow, Johns Hopkins Univ. (United States)
Nicholas J. Durr, Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 10871:
Multimodal Biomedical Imaging XIV
Fred S. Azar; Xavier Intes; Qianqian Fang, Editor(s)

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