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Proceedings Paper

Noninvasive imaging of dual-agent uptake in glioma and normal tissue using MRI-coupled fluorescence tomography
Author(s): Boyu Meng; Margaret R. Folaron; Rendall R. Strawbridge; Negar Sadeghipour; Kimberley S. Samkoe; Kenneth Tichauer; Scott C. Davis
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Paper Abstract

As the role of immuno-oncological therapeutics expands, the capacity to noninvasively quantify molecular targets and drug-target engagement is increasingly critical to drug development efforts and treatment monitoring. Previously, we showed that MRI-coupled dual-agent fluorescence tomography (FMT) is capable of estimating the concentration of epidermal growth factor receptor (EGFR) in orthotopic glioma models noninvasively. This approach uses the dynamic information of two fluorescent agents (a targeted agent and untargeted isotype) to estimate tumor receptor concentration in vivo. This approach generally relies on the two tracers having similar kinetics in normal tissues, which may not always be the case. Herein, we describe an additional channel added to the MRI-FMT system which measures the uptake of both agents in the normal muscle, data which can be used to compensate for differing kinetic behavior.

Paper Details

Date Published: 1 March 2019
PDF: 6 pages
Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 1087413 (1 March 2019); doi: 10.1117/12.2510515
Show Author Affiliations
Boyu Meng, Dartmouth College (United States)
Margaret R. Folaron, Dartmouth College (United States)
Rendall R. Strawbridge, Dartmouth College (United States)
Negar Sadeghipour, Illinois Institute of Technology (United States)
Kimberley S. Samkoe, Dartmouth College (United States)
Kenneth Tichauer, Illinois Institute of Technology (United States)
Scott C. Davis, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 10874:
Optical Tomography and Spectroscopy of Tissue XIII
Sergio Fantini; Bruce J. Tromberg; Eva Marie Sevick-Muraca; Paola Taroni, Editor(s)

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