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Proceedings Paper

Evaluation of metastatic potential of circulating tumor cells using quantitative phase imaging (QPI)
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Paper Abstract

Revealing and characterization of circulating tumor cells (CTCs) is one of the most actively investigated field of oncology. It was established by the past time studies that some of these cells were in condition of apoptosis and so couldn’t initiate formation of a clinically significant metastasis. The novel opportunities associated with development of computer technologies and interferential microscopes facilitate the solution of many medico-biological problems. One of them is a method of determination of CTCs functional condition based on the phase-interferential characteristics of their nuclear structures which reflect cellular metabolic and proliferative activity and are the markers of their malignant transformation.

The analysis was carried out of the morphodensitometric biomarkers of the metastatic activity of circulating tumorous cells including conformational alterations of their nuclear structures. The reference collection of phase images of metastatic cells was created as well as the data of the morphodensitometric parameters of their metabolic activity was received.

A new information was received about heterogeneity of the circulating tumorous cells with different metastatic activity which allows the broadening of fundamental scientific knowledge concerning cancerogenesis, individualization of the observation and treatment of patients, improvement of the quality of treatment, and optimization of its cost.

Paper Details

Date Published: 4 March 2019
PDF: 6 pages
Proc. SPIE 10887, Quantitative Phase Imaging V, 1088724 (4 March 2019); doi: 10.1117/12.2510383
Show Author Affiliations
Irina Vasilenko, A.N. Kosygin Russian State Univ. (Russian Federation)
M.F. Vladimirsky Moscow Regional Research and Clinical Institute (Russian Federation)
Vladislav Metelin, A.N. Kosygin Russian State Univ. (Russian Federation)
M.F. Vladimirsky Moscow Regional Research and Clinical Institute (Russian Federation)
Ziver Kardasheva, A.N. Kosygin Russian State Univ. (Russian Federation)
M.F. Vladimirsky Moscow Regional Research and Clinical Institute (Russian Federation)
Andrey Balkanov, M.F. Vladimirsky Moscow Regional Research and Clinical Institute (Russian Federation)
Roman Lifenko, Mineralovodskaya Interdistrict Maternity Hospital (Russian Federation)


Published in SPIE Proceedings Vol. 10887:
Quantitative Phase Imaging V
Gabriel Popescu; YongKeun Park, Editor(s)

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