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Proceedings Paper

A multi spectral hand-held spatial frequency domain imaging system for imaging human colorectal cancer
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Paper Abstract

A multi-spectral, portable, hand-held LED based spatial frequency domain imaging system was used for ex vivo imaging pretreatment and post treatment human colon and rectal tissues. Freshly excised human colon and rectal tissue samples were imaged with the hand-held SFDI probe with 9 wavelengths extending from visible to NIR (660-950 nm). Important tumor biomarkers such as hemoglobin, scatter amplitude, scatter spectral slope, water and lipid content were quantitatively extracted from the SFDI absorption and scattering images. Significant differences were observed between the absorption as well as scattering distribution of normal, tumor and polyp tissue as well as between pretreated and post-treated tumors.

Paper Details

Date Published: 1 March 2019
PDF: 3 pages
Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108740T (1 March 2019); doi: 10.1117/12.2510320
Show Author Affiliations
Yifeng Zeng, Washington Univ. in St. Louis (United States)
Shuying Li, Washington Univ. in St. Louis (United States)
Mohsen Erfanzadeh, Univ. of Connecticut (United States)
Sreyankar Nandy, Washington Univ. in St. Louis (United States)
William Chapman Jr., Washington Univ. in St. Louis (United States)
Zahra Alipour, Washington Univ. in St. Louis (United States)
Heba Abdelal, Washington Univ. in St. Louis (United States)
Deyali Chatterjee, Washington Univ. School of Medicine in St. Louis (United States)
Matthew Mutch, Washington Univ. School of Medicine in St. Louis (United States)
Quing Zhu, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 10874:
Optical Tomography and Spectroscopy of Tissue XIII
Sergio Fantini; Bruce J. Tromberg; Eva Marie Sevick-Muraca; Paola Taroni, Editor(s)

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