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Proceedings Paper

Fluorescence lifetime imaging microscopy along with non-Euclidean phasor analysis for visualization of drug distribution of a topical drug in human facial skin (Conference Presentation)

Paper Abstract

We recently proposed a method for selective visualization of topical drug distribution within human facial skin using two-photon fluorescence lifetime imaging along with non-Euclidean phasor analysis as a pharmacokinetics and pharmacodynamics imaging toolkit. In order to improve the efficacy of topical drug delivery toward the treatment of inflammatory acne, we have now developed a combination topical gel containing both minocycline and a retinoid. Since both drugs have unique fluorescence lifetimes compared to skin, we were able to selectively visualize the distribution of minocycline and the retinoid within ex vivo human facial skin while isolating the contributions of the three components.

Paper Details

Date Published: 4 March 2019
Proc. SPIE 10859, Visualizing and Quantifying Drug Distribution in Tissue III, 1085908 (4 March 2019); doi: 10.1117/12.2510218
Show Author Affiliations
Sinyoung Jeong, Massachusetts General Hospital (United States)
Alexander Fast, Massachusetts General Hospital (United States)
Sam Osseiran, Massachusetts General Hospital (United States)
Harvard-MIT Health Sciences and Technology (United States)
Maiko Hermsmeier, BioPharmX, Inc. (United States)
Tanvee Sawant, BioPharmX, Inc. (United States)
Kin F. Chan, BioPharmX, Inc. (United States)
Conor L. Evans, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 10859:
Visualizing and Quantifying Drug Distribution in Tissue III
Kin Foong Chan; Conor L. Evans, Editor(s)

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