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Proceedings Paper

Intraoperative molecular chemical imaging endoscopy for the in vivo detection of anatomical structures (Conference Presentation)
Author(s): Shona D. Stewart; Aaron Smith; Heather Gomer; Jihang Wang; Charles Gardner; James C. Post; Jeffrey Cohen; Patrick Treado

Paper Abstract

Accurate identification, precise dissection, and careful preservation of critical structures, such as nerves and blood vessels, are key to successful surgical outcomes. Unintended and/or unrecognized injuries to critical structures result in debilitating short- and long-term morbidity, avoidable mortality, and considerable socioeconomic and healthcare burdens. ChemImage has developed a Molecular Chemical Imaging endoscope (MCI-E) to be deployed as an intraoperative imaging device for real-time detection of key anatomical structures. MCI-E does not require the use of contrast agents, and employs visible-near infrared (vis-NIR) reflectance hyperspectral imaging. We tested the in vivo performance of MCI-E by collecting high quality vis-NIR signatures from several anatomical structures, including ureters, arteries, and veins in live pigs under general anesthesia. In this paper, we will present successful MCI-E detection of lymph node, ureter, vessels, nerve, bowel, and thyroid in background tissues under relevant in vivo conditions. If successful, integration of MCI-E into surgical procedures will enable real-time automated detection of anatomical structures during surgeries. The benefits of this capability include the opportunity of reduced surgery time, decreased patient risk, fewer repeat surgeries, and enhancement of surgeon training.

Paper Details

Date Published: 7 March 2019
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Proc. SPIE 10868, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII, 108680O (7 March 2019); doi: 10.1117/12.2510216
Show Author Affiliations
Shona D. Stewart, ChemImage Corp. (United States)
Aaron Smith, ChemImage Corp. (United States)
Heather Gomer, ChemImage Corp. (United States)
Jihang Wang, ChemImage Corp. (United States)
Charles Gardner, ChemImage Corp. (United States)
James C. Post, Allegheny Health Network (United States)
Jeffrey Cohen, Allegheny Health Network (United States)
Patrick Treado, ChemImage Corp. (United States)


Published in SPIE Proceedings Vol. 10868:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII
Anita Mahadevan-Jansen, Editor(s)

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