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Proceedings Paper

Differentiation of murine colon pathology by optical and mechanical contrast using optical coherence tomography and elastography
Author(s): Achuth Nair; Susobhan Das; Chih-Hao Liu; Manmohan Singh; Triet Le; Salavat Aglyamov; Yong Du; Sanam Soomro; Chandra Mohan; Kirill V. Larin
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Paper Abstract

Colon pathologies including colon cancer and ulcerative colitis afflict hundreds of thousands of people in the United States. Clinical detection of colon diseases is generally performed through colonoscopy. However, these methods usually lack the sensitivity or resolution to detect diseased tissue at early stages. Even high resolution optical techniques such as confocal microscopy and optical coherence tomography (OCT) rely on structural features to detect anomalies in tissue, which may not be sufficient for early disease detection. If changes in tissue biomechanical properties precede morphological changes in tissue physiology, then mechanical contrast would enable earlier detection of disease. In this work, we utilized optical coherence elastography (OCE) to assess the biomechanical properties of healthy, cancerous, and colitis tissue. Additionally, the optical properties of each sample were also assessed as a secondary feature to distinguish tissue types. The Young’s modulus, as measured by the propagation of an elastic wave, of the healthy, cancerous, and colitis tissue was 10.8 ± 1.0 kPa, 7.12 ± 1.0 kPa, and 5.1 ± 0.1 kPa, respectively. The variations in the OCT signal intensity over depth, as measured by the slope-removed standard deviation of each A-scan was 5.8 ±.0.3 dB, 5.1 ± 0.4 dB, and 5.5 ± 0.2 dB for healthy, cancerous, and colitis tissue, respectively. This work shows OCT structural imaging combined with OCE can detect minute changes in colon tissue optical scattering and elastic properties, which may be useful for detection various colon diseases, such as colitis and colon cancer.

Paper Details

Date Published: 21 February 2019
PDF: 7 pages
Proc. SPIE 10880, Optical Elastography and Tissue Biomechanics VI, 108800P (21 February 2019); doi: 10.1117/12.2510183
Show Author Affiliations
Achuth Nair, Univ. of Houston (United States)
Susobhan Das, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Triet Le, Univ. of Houston (United States)
Salavat Aglyamov, Univ. of Houston (United States)
Unive. of Texas at Austin (United States)
Yong Du, Univ. of Houston (United States)
Sanam Soomro, Univ. of Houston (United States)
Chandra Mohan, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)
Tomsk State Univ. (Russian Federation)
Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 10880:
Optical Elastography and Tissue Biomechanics VI
Kirill V. Larin; Giuliano Scarcelli, Editor(s)

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