Share Email Print

Proceedings Paper

Monitoring total hemoglobin concentration changes across neoadjuvant chemotherapy in PgR-positive and PgR-negative breast cancer with diffuse optical tomography
Author(s): Mirella L. Altoe; Alessandro Marone; Hyun K. Kim; Mariella Tejada; Hanina Hibshoosh; Katherine Crew; Kevin Kalinsky; Dawn L. Hershman; Andreas H. Hielscher
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

The aim of this study was to investigate the optical chemotherapy changes induced by neoadjuvant chemotherapy (NAC) in PgR-positive and PgR-negative breast cancer subtypes using a diffuse optical tomographic breast imaging system (DOTBIS). ctTHb reduction in the tumor volume was greater for patients with PgR-negative, a statistically significant difference of 48.91μM, p = .022, which suggest that PgR-negative tumors are generally less resistant to NAC. These observations indicate that PgR negativity may be combined to optically derived biomarkers for predicting pCR during neoadjuvant chemotherapy.

Paper Details

Date Published: 1 March 2019
PDF: 5 pages
Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741L (1 March 2019); doi: 10.1117/12.2510172
Show Author Affiliations
Mirella L. Altoe, Columbia Univ. (United States)
Alessandro Marone, Columbia Univ. (United States)
Hyun K. Kim, Columbia Univ. (United States)
Mariella Tejada, Herbert Irving Comprehensive Cancer Ctr. (United States)
Hanina Hibshoosh, Columbia Univ. (United States)
Katherine Crew, Columbia Univ. (United States)
Kevin Kalinsky, Columbia Univ. (United States)
Dawn L. Hershman, Columbia Univ. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)

Published in SPIE Proceedings Vol. 10874:
Optical Tomography and Spectroscopy of Tissue XIII
Sergio Fantini; Bruce J. Tromberg; Eva Marie Sevick-Muraca; Paola Taroni, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?