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Proceedings Paper

Oxygenation based perfusion assessment of diabetic foot ulcers using a breath-hold paradigm
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Paper Abstract

Diabetic Foot Ulcers (DFUs) are responsible for 20% of diabetic-related hospitalization and 85% of diabetes related amputations. In DFUs the primary factor affecting healing is an adequate oxygen supply to the wound. However, the gold standard approach for assessing DFUs is by evaluating the reduction of wound size over a four-week period. In this study, we investigate the potential of altered breathing patterns as a technique to assess localized oxygenated perfusion in DFUs as a measure of healing potential. A continuous wave (CW), non-contact, near infrared optical scanner (NIROS) was used to conduct NIR based spectroscopic imaging at dual discrete wavelengths (729nm and 799nm) on DFUs with 7mW of maximum optical power. Subjects were imaged at discrete time points and dynamically utilizing an altered breathing paradigm (i.e. breath-hold) to measure the relative oxy- (ΔHbO) and deoxyhemoglobin (ΔHbR) changes in normal and DFU scenarios. Results show that in normal individuals, ΔHbO/ΔHbR changes at all points of the foot because of altered breathing patterns are synchronous; whereas in the DFU scenario changes in hemodynamic parameters are asynchronous. This indicates that under normal circumstances, oxygenated perfusion changes are consistent and uniform at all points of the foot as opposed to the DFU scenario’s inconsistent oxygenated perfusion. Altered breathing paradigms may serve as a useful tool in assessing localized sub-surface oxygenated perfusion in regions around the wound, and help clinicians better cater the treatment process.

Paper Details

Date Published: 4 March 2019
PDF: 5 pages
Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1087304 (4 March 2019); doi: 10.1117/12.2509917
Show Author Affiliations
Kevin Leiva, Florida International Univ. (United States)
Jagadeesh Mahadevan, Florida International Univ. (United States)
Priscilla Lozano, Florida International Univ. (United States)
Kacie Kaile, Florida International Univ. (United States)
Richard Schutzman, Florida International Univ. (United States)
Edwin Robledo, Florida International Univ. (United States)
Dinesh Khandavilli, Florida International Univ. (United States)
Sivakumar Narayanan, Dr. Mohan's Diabetes Specialities Ctr. (India)
Varalakshmi Muthukrishnan, Dr. Mohan's Diabetes Specialities Ctr. (India)
Mohan Viswanathan, Dr. Mohan's Diabetes Specialities Ctr. (India)
Wensong Wu, Florida International Univ. (United States)
Anuradha Godavarty, Florida International Univ. (United States)

Published in SPIE Proceedings Vol. 10873:
Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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