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Proceedings Paper

Compact modules for off-axis holography in microfluidics: features and design solutions
Author(s): V. Bianco; T. Cacace; B. Mandracchia; V. Pagliarulo; M. Paturzo; P. Ferraro
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Paper Abstract

The diffusion of miniaturized analysis platforms has spurred the development of portable and compact imaging systems. We present a compact, lens-based imaging module that implements wavefront division off-axis holography on a commercial microfluidic chip, thanks to the insertion of a diffraction grating. The initial architecture is realized in three configurations. Different positioning of the grating respect to the microfluidic channel (parallel and orthogonal) are explored, and an enhancement of the imaging system compactness and price-effectiveness is realized by further functionalizing the chip with micro-optics. The three configurations are separately analyzed and tested. It is demonstrated that the characteristic features of Digital Holography, i.e. label-free imaging, quantitative phase mapping and flexible refocusing, are preserved, and differences and specific fields of applicability are highlighted.

Paper Details

Date Published: 26 February 2019
PDF: 6 pages
Proc. SPIE 10869, Optics and Biophotonics in Low-Resource Settings V, 108690S (26 February 2019); doi: 10.1117/12.2509527
Show Author Affiliations
V. Bianco, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
T. Cacace, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
Univ. Campania L. Vanvitelli (Italy)
B. Mandracchia, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
V. Pagliarulo, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
M. Paturzo, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
P. Ferraro, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)


Published in SPIE Proceedings Vol. 10869:
Optics and Biophotonics in Low-Resource Settings V
David Levitz; Aydogan Ozcan, Editor(s)

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