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Proceedings Paper

Terahertz pulse time-domain holography method for phase imaging of breast tissue
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Paper Abstract

Pulse holographic imaging along with time-domain spectroscopy scan and tomographic techniques are of great interest. Since the advantages of holography are the lack of focusing optics and high spatial resolution, and, comparing with tomography, less computation cost for numerical reconstruction, this technique is preferable for the analysis of thin histological samples. In this work we have created the experimental scheme that involves measurement of diffraction pattern of the collimated THz pulse field spatial distribution at some distance behind the object in the time-domain mode, thus allowing reconstruction of amplitude and phase distribution at the object plane by numerical backpropagation of the wavefront in the spectral domain. In our experiment, we used a breast biopsy sample containing cancer tissues, we also performed numerical simulations accounting for experimental conditions to confirm the conceptual applicability of the reconstruction method.

Paper Details

Date Published: 4 March 2019
PDF: 7 pages
Proc. SPIE 10887, Quantitative Phase Imaging V, 108870G (4 March 2019); doi: 10.1117/12.2508711
Show Author Affiliations
Nikolay S. Balbekin, ITMO Univ. (Russian Federation)
Quentin Cassar, IMS Lab., CNRS, Univ. de Bordeaux (France)
Olga A. Smolyanskaya, ITMO Univ. (Russian Federation)
Maksim S. Kulya, ITMO Univ. (Russian Federation)
Nikolay V. Petrov, ITMO Univ. (Russian Federation)
Gaetan MacGrogan, Bergonie Institute (France)
Jean-Paul Guillet, IMS Lab., CNRS, Univ. de Bordeaux (France)
Patrick Mounaix, IMS Lab., CNRS, Univ. de Bordeaux (France)
Valery V. Tuchin, ITMO Univ. (Russian Federation)
Saratov State Univ. (Russian Federation)
Institute of Precision Mechanics and Control (Russian Federation)

Published in SPIE Proceedings Vol. 10887:
Quantitative Phase Imaging V
Gabriel Popescu; YongKeun Park, Editor(s)

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