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Proceedings Paper

Image-guided photo-mediated ultrasound therapy as a novel method for treating eye diseases (Conference Presentation)
Author(s): Xinyi Xie; Yu Qin; Wei Zhang; Songtao Yuan; Qinghuai Liu; Qian Cheng; Yannis Mantas Paulus; Xinmai Yang; Xueding Wang

Paper Abstract

Ocular neovascularization occurs in various eye diseases such as diabetic retinopathy, neovascular macular degeneration, and retinopathy of prematurity. Current treatment methods including conventional laser ablation therapy and anti-vascular endothelial growth factor (VEGF) injection each has drawbacks including collateral tissue damages, frequent administration, high cost, and drug toxicity. We recently developed a novel noninvasive image-guided photo-mediated ultrasound therapy (PUT) which concurrently applies nanosecond laser pulses and millisecond ultrasound bursts to precisely and safely remove pathologic microvessels in the eye. Relying on the mechanism of photoacoustic cavitation, PUT takes advantages of high optical contrast among biological tissues, and can selectively remove microvessels without causing collateral tissue damage. To achieve personalized treatment with optimal treatment outcome, a multi-modality eye imaging system involving advanced photoacoustic microscopy (PAM) and optical coherence tomography (OCT) has been integrated with the PUT system to provide real-time feedback and online evaluation of the treatment outcome. To assess the performance of this image-guided PUT system, experiments have been conducted on rabbit eye models. During the treatment, cavitation signals were observed and monitored by OCT with good sensitivity, suggesting that OCT can be used to evaluate treatment effect in real time. The PAM was capable of mapping the 3D distributed microvessels with excellent image quality, demonstrating that PAM can help to quantitatively evaluate the treatment outcome. As indicated by the initial results from this study, imaging guidance involving both PAM and OCT could further improve the efficacy and safety of the newly invented PUT, accelerating its translation to ophthalmology clinic.

Paper Details

Date Published: 4 March 2019
Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108780H (4 March 2019); doi: 10.1117/12.2507680
Show Author Affiliations
Xinyi Xie, Univ. of Michigan (United States)
Nanjing Medical Univ. (China)
Yu Qin, Univ. of Michigan (United States)
Wei Zhang, Univ. of Michigan (United States)
Songtao Yuan, Nanjing Medical Univ. (China)
Qinghuai Liu, Nanjing Medical Univ. (China)
Qian Cheng, Tongji Univ. (China)
Yannis Mantas Paulus, Univ. of Michigan (United States)
Xinmai Yang, The Univ. of Kansas (United States)
Xueding Wang, Univ. of Michigan (United States)
Tongji Univ. (China)

Published in SPIE Proceedings Vol. 10878:
Photons Plus Ultrasound: Imaging and Sensing 2019
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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