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Proceedings Paper

Multiphoton imaging of the toxic effect of carbon tetrachloride on hepatobiliary metabolism in vivo
Author(s): Hsu-Cheng Huang; Chih-Ju Lin; Sheng-Lin Lee; Hsuan-Shu Lee; Chen-Yuan Dong
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Paper Abstract

We used intravital multiphoton microscopy to study the recovery of hepatobiliary metabolism following carbon tetrachloride (CCl4) induced hepatotoxicity in mouse. Our images were processed by a first order kinetic model to generate rate constant resolved images of the mouse liver. At Day 14 following induction, a restoration of the mouse hepatobiliary function was found. Our approach allows the study of the response of hepatic functions to chemical agents in real time and is useful for studying pharmacokinetics of drug molecules through optical microscopic imaging.

Paper Details

Date Published: 28 February 2019
PDF: 6 pages
Proc. SPIE 10859, Visualizing and Quantifying Drug Distribution in Tissue III, 108590B (28 February 2019); doi: 10.1117/12.2507347
Show Author Affiliations
Hsu-Cheng Huang, National Taiwan Univ. (Taiwan)
Chih-Ju Lin, National Taiwan Univ. (Taiwan)
Sheng-Lin Lee, National Taiwan Univ. (Taiwan)
Hsuan-Shu Lee, National Taiwan Univ. Hospital (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)


Published in SPIE Proceedings Vol. 10859:
Visualizing and Quantifying Drug Distribution in Tissue III
Kin Foong Chan; Conor L. Evans, Editor(s)

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