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Proceedings Paper

In vivo photoacoustic imaging of liver using liver specific targeting conjugates
Author(s): Donghyun Lee; Chulhong Kim
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Paper Abstract

The liver performs important functions in our body such as protein synthesis, and blood cell degradation has been considered a major organ of the human body. Currently, ultrasound imaging and magnetic resonance imaging are frequently used to diagnose liver diseases including cancer and cirrhosis. Ultrasound imaging is commonly used for liver disease because it provides safe, easy-to-use, real-time imaging at low cost. Ultrasound uses anatomical, tissue, and blood flow information to diagnose liver disease. By adding additional information using photoacoustic (PA) imaging, the diagnosis of the liver disease can be further enhanced. In this study, we developed hyaluronate silica nanoparticles (HASi) PA contrast agents that can be targeted to liver specifically. Since the hyaluronic acid receptors such as cluster determinant 44 are overexpressed in the liver, hyaluronic acid is considered a direct marker for fibrogenesis. Therefore, hyaluronic acid conjugates have been researched for liver-specific targeting. To verify liver-specific targeting efficiency and PA contrast agent property, in vivo PA monitoring has been conducted after i.v. injection of HA-Si and silica nanoparticles. ICP-MS analysis of major organs and urine optical absorbance spectra analysis has been performed to investigate biocompatibility of HA-Si. These results demonstrate the possibility of liver-specific drug delivery of the hyaluronic acid complex and the possibility of a PA method for liver lesion monitoring.

Paper Details

Date Published: 27 February 2019
PDF: 4 pages
Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 1087863 (27 February 2019); doi: 10.1117/12.2506563
Show Author Affiliations
Donghyun Lee, Pohang Univ. of Science and Technology (Korea, Republic of)
Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of)

Published in SPIE Proceedings Vol. 10878:
Photons Plus Ultrasound: Imaging and Sensing 2019
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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