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Proceedings Paper

Perfluorocarbon compounds: transmitting liquids for infrared laser tissue ablation
Author(s): Martin Frenz; Hans Surya Pratisto; Cynthia A. Toth M.D.; E. Duco Jansen; Hans Joerg Altermatt; Ashley J. Welch; Heinz P. Weber
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Paper Abstract

One concern during IR-laser ablation of tissue under water is the mechanical injury that may be induced in tissue due to rapid bubble expansion and collapse or due to strong laser-induced pressure waves. The objective of this study was to evaluate the feasibility of using a liquid which is transparent to the IR-region of the spectrum in order to minimize these undesired mechanical side-effects. As transmitting medium perfluorocarbon liquid was used. Free- running Er:YAG and Ho:YAG laser pulses were delivered into the liquid via a 400 micrometers fiber. Bubble formation during the ablation process was recorded with fast flash photography while pressure transients were measured with a needle hydrophone. The effect of the surrounding material (air, water, perfluorooctane) on the tissue response of chicken breast was evaluated in vitro using histology. It was observed that a large bubble (up to 6 mm in diameter) was formed under perfluorooctane driven by the ablation products. This bubble, however, does not generate a pressure wave when collapsing. Although perfluorooctane only shows a weak absorption for infrared radiation, laser-induced thermal lensing in the liquid strongly decreases the radiant exposure and therefore the ablation efficiency.

Paper Details

Date Published: 7 May 1996
PDF: 10 pages
Proc. SPIE 2681, Laser-Tissue Interaction VII, (7 May 1996); doi: 10.1117/12.239593
Show Author Affiliations
Martin Frenz, Univ. Bern and Univ. of Texas/Austin (United States)
Hans Surya Pratisto, Univ. Bern (United States)
Cynthia A. Toth M.D., Duke Univ. Eye Ctr. (United States)
E. Duco Jansen, Univ. of Texas/Austin (United States)
Hans Joerg Altermatt, Univ. Bern (Switzerland)
Ashley J. Welch, Univ. of Texas/Austin (United States)
Heinz P. Weber, Univ. Bern (Switzerland)

Published in SPIE Proceedings Vol. 2681:
Laser-Tissue Interaction VII
Steven L. Jacques, Editor(s)

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