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Proceedings Paper

Segmentation and analysis of breast cancer pathological images by an adaptive-sized hybrid neural network
Author(s): Akira Hasegawa; Kevin J. Cullen M.D.; Seong Ki Mun
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Paper Abstract

The number of nuclei on a pathology image assists pathologists in consistent diagnosis of breast cancer. Currently, most pathologists make a diagnosis based on a rough estimation of the number of nuclei on pathology images. Because of the rough estimation, the diagnosis is not objective. To assist pathologists to make a consistent, objective and fast diagnosis, it is necessary to develop a computer system to automatically recognize and count several kinds of nuclei. We have developed an algorithm for the automatic segmentation and counting of nuclei in breast cancer pathology images. In the development of the algorithm, we proposed two novel methods: an adaptive-sized hybrid neural network for the automatic segmentation of nuclei, insulin-like growth factor-II messenger RNAs and other structures, and the combined use of both the focused gradient filter and the watersheds algorithm for segmentation of overlapped nuclei.

Paper Details

Date Published: 16 April 1996
PDF: 11 pages
Proc. SPIE 2710, Medical Imaging 1996: Image Processing, (16 April 1996); doi: 10.1117/12.237980
Show Author Affiliations
Akira Hasegawa, Georgetown Univ. Medical Ctr. (United States)
Kevin J. Cullen M.D., Georgetown Univ. Medical Ctr. (United States)
Seong Ki Mun, Georgetown Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 2710:
Medical Imaging 1996: Image Processing
Murray H. Loew; Kenneth M. Hanson, Editor(s)

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