We have been developing phase-contrast x-ray computed tomography (CT) to make possible the observation of biological soft tissues without contrast enhancement. Phase-contrast x-ray CT requires for its input data the x-ray phase-shift distributions or phase-mapping images caused by an object. These were measured with newly developed fringe-scanning x-ray interferometry. Phase-mapping images at different projection directions were obtained by rotating the object in an x-ray interferometer, and were processed with a standard CT algorithm. A phase-contrast x-ray CT image of a nonstained cancerous tissue was obtained using 17.7 keV synchrotron x rays with 12 micrometer voxel size, although the size of the observation area was at most 5 mm. The cancerous lesions were readily distinguishable from normal tissues. Moreover, fine structures corresponding to cancerous degeneration and fibrous tissues were clearly depicted. It is estimated that the present system is sensitive down to a density deviation of 4 mg/cm³.

Date Published: 11 April 1996
PDF: 11 pages
Proc. SPIE 2708, Medical Imaging 1996: Physics of Medical Imaging, (11 April 1996); doi: 10.1117/12.237831

Published in SPIE Proceedings Vol. 2708:
Medical Imaging 1996: Physics of Medical Imaging
Richard L. Van Metter; Jacob Beutel, Editor(s)