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Proceedings Paper

Laser desorption mass spectrometry for molecular diagnosis
Author(s): C. H. Winston Chen; N. I. Taranenko; Y. F. Zhu; S. L. Allman; K. Tang; K. J. Matteson; L. Y. Chang; C. N. Chung; Steve Martin; Lawrence Haff
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Paper Abstract

Laser desorption mass spectrometry has been used for molecular diagnosis of cystic fibrosis. Both 3-base deletion and single-base point mutation have been successfully detected by clinical samples. This new detection method can possibly speed up the diagnosis by one order of magnitude in the future. It may become a new biotechnology technique for population screening of genetic disease.

Paper Details

Date Published: 1 April 1996
PDF: 9 pages
Proc. SPIE 2680, Ultrasensitive Biochemical Diagnostics, (1 April 1996); doi: 10.1117/12.237634
Show Author Affiliations
C. H. Winston Chen, Oak Ridge National Lab. (United States)
N. I. Taranenko, Oak Ridge National Lab. (United States)
Y. F. Zhu, Oak Ridge National Lab. (United States)
S. L. Allman, Oak Ridge National Lab. (United States)
K. Tang, Vanderbilt Univ. (United States)
K. J. Matteson, Univ. of Tennessee Medical Ctr. (United States)
L. Y. Chang, Univ. of Tennessee Medical Ctr. (United States)
C. N. Chung, Univ. of Illinois (United States)
Steve Martin, PerSeptive Biosystems, Inc. (United States)
Lawrence Haff, PerSeptive Biosystems, Inc. (United States)

Published in SPIE Proceedings Vol. 2680:
Ultrasensitive Biochemical Diagnostics
Gerald E. Cohn; Steven A. Soper; C. H. Winston Chen, Editor(s)

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