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Proceedings Paper

New sensitizers and rapid monitoring of their photodynamic activity
Author(s): Nadezgda L. Torshina; Anna M. Posypanova; Anna I. Volkova
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Paper Abstract

At present, there are lots and lots of chemical compounds that are, to a certain extent, photodynamically active. Therefore, the task of carrying out the expressive screening of such compounds has been raised sharply enough. The primary screening in vitro of compounds, with the help of biological liquids, is notable for quickness and cheapness at the same time, it is possible to determine the comparative characteristics of compounds by their photodynamical activity. Decomposition of albumins of a mixture of photosensitizer and biological liquid when irradiating with light is the basis of this method. Efficiency of decomposition of components of biological liquids is determined using biochemical reactions (e.g., those for determining the total albumins or blood hemoglobin). Subsequently, with a sufficient efficiency of a photosensitizer, it will be possible to carry out a study in vivo, with the purpose of establishing accumulation of preparations in tumor.

Paper Details

Date Published: 2 April 1996
PDF: 2 pages
Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237546
Show Author Affiliations
Nadezgda L. Torshina, General Physics Institute (Russia)
Anna M. Posypanova, General Physics Institute (Russia)
Anna I. Volkova, General Physics Institute (Russia)


Published in SPIE Proceedings Vol. 2675:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V
Thomas J. Dougherty, Editor(s)

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