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Proceedings Paper

Photodynamic therapy using a diode laser with mono-L-aspartyl chlorin e6 (NPe6)
Author(s): Kinya Furukawa M.D.; Tohichiro Katsumi; Hiroshi Shibuya; Tetsuya Okunaka; Yukari Kuroiwa; Yoshiteru Ii; Akira Kaneda; Kouichi Saito; Chimori Konaka; Katsuo Aizawa; Harubumi Kato M.D.
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Paper Abstract

The authors developed a new high-power red laser diode system (Matsushita Industrial Equipment Co., Ltd., Osaka) for photodynamic therapy (PDT) with mono-L-aspartyl chlorin e6 (NPe6, Meiji Seika Kaisha LTD.). The laser wavelength was adjusted to 664 nm and the power output could be varied in the range of 50-500 mW at the fiber tip in a continuous wave (cw) mode. The delivered energy could be adjusted from 50 - 1000 J. The system has a size of 49 by 20 by 40 cm, weighs 20 kg, and is readily portable. It runs on 100 V current. The laser power is easily controlled and the wavelength is stable (less than plus or minus 0.2 nm). The output beam is delivered via a quartz fiber. Furthermore, the full width at half-maximum power is less than 2 nm, which enables uniform, high-density photoirradiation. The power density distribution of the laser, analyzed by a CCD camera, was uniform throughout the photoirradiated field. In an animal study, tumor-bearing Balb/c mice were treated with the diode laser 5 hours after intravenous administration of NPe6 at a dose of 1.25 to 12.5 mg/kg i.v.. Total photoirradiation ranged from 3.13 to 250 J/cm2 which the energy density was adjusted to 100 mW/cm2. Percentages of cures were determined histopathologically from numbers of mice apparently disease-free 1 week after treatment. The results show that a laser energy of more than 12.5 J/cm2 was necessary to obtain 90% tumor cure rate at a maximum dose of NPe6 (12.5 mg/kg) and NPe6 dose of more than 2.5 mg/kg was necessary to obtain 90% cure rate at high laser energy of 200 J/cm2.

Paper Details

Date Published: 2 April 1996
PDF: 6 pages
Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237541
Show Author Affiliations
Kinya Furukawa M.D., Tokyo Medical College (Japan)
Tohichiro Katsumi, Tokyo Medical College (Japan)
Hiroshi Shibuya, Tokyo Medical College (Japan)
Tetsuya Okunaka, Tokyo Medical College (Japan)
Yukari Kuroiwa, Tokyo Medical College (Japan)
Yoshiteru Ii, Matsushita Industrial Equipment Co., Ltd. (Japan)
Akira Kaneda, Matsushita Industrial Equipment Co., Ltd. (Japan)
Kouichi Saito, Tokyo Medical College (Japan)
Chimori Konaka, Tokyo Medical College (Japan)
Katsuo Aizawa, Tokyo Medical College (Japan)
Harubumi Kato M.D., Tokyo Medical College (Japan)

Published in SPIE Proceedings Vol. 2675:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V
Thomas J. Dougherty, Editor(s)

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