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Proceedings Paper

Infrared spectroscopy criteria for diagnostics selection of patients with ovarian cancer for further molecular genetic studies
Author(s): I. Gruia; S. B. Yermolenko; O. P. Peresunko; Bin Guo; Zhebo Chen
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Paper Abstract

The article is devoted to the substantiation of the selection of patients with ovarian cancer (OC) for the purpose of conducting expensive molecular genetic studies on genotyping, namely the identification of gene of hereditary predisposition of OC (BRCA1 and BRCA2). The proposed method makes it possible at the first stage to find among all patients with ovarian the proposed individuals whose further molecular genetic studies will objectively confirm the diagnosis of hereditary cancer (by genotyping on (BRCA I and II), which significantly reduces the cost of these studies in the population. The object of the study during infrared spectrometry (IR spectrometry) was plasma blood of patients with a verified diagnosis of ovarian cancer (35 patients - 1 group), as well as healthy (30 - control group). A preliminary data show that the optical method of infrared plasma spectroscopy of patients with ovarian cancer patients needs further research as a test screening method for the diagnosis of hereditary ovarian cancer as a preliminary selection of patients for molecular genetic studies (BRCA I and II).

Paper Details

Date Published: 31 December 2018
PDF: 7 pages
Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 1097734 (31 December 2018); doi: 10.1117/12.2323599
Show Author Affiliations
I. Gruia, Univ. of Bucharest (Romania)
S. B. Yermolenko, Chernivtsi National Univ. (Ukraine)
O. P. Peresunko, Bukovinian State Medical Univ. (Ukraine)
Bin Guo, Taizhou Institute of Science & Technology (China)
Zhebo Chen, Taizhou Institute of Science & Technology (China)


Published in SPIE Proceedings Vol. 10977:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX
Marian Vladescu; Razvan D. Tamas; Ionica Cristea, Editor(s)

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