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Proceedings Paper

Pore-forming proteins with built-in triggers and switches
Author(s): Hagan Bayley
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Paper Abstract

Genetic engineering and targeted chemical modification are being used to produce polypeptides with pore-forming activity that can be triggered or switched on-and-off by biochemical, chemical or physical stimuli. The principal target of our studies has been the (alpha) -hemolysin ((alpha) HL) from the bacterium Staphylococcus aureus. The remodeled hemolysins include protease-activated pores, metal-regulated pores, pores that are activated by chemical alkylation and pores that are turned on with light. These polypeptides have several potential applications. For example, they might serve as components of sensors or they might be useful for mediating the controlled release of encapsulated drugs.

Paper Details

Date Published: 9 February 1996
PDF: 4 pages
Proc. SPIE 2716, Smart Structures and Materials 1996: Smart Materials Technologies and Biomimetics, (9 February 1996); doi: 10.1117/12.232159
Show Author Affiliations
Hagan Bayley, Worcester Foundation for Biomedical Research (United States)

Published in SPIE Proceedings Vol. 2716:
Smart Structures and Materials 1996: Smart Materials Technologies and Biomimetics
Andrew Crowson, Editor(s)

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