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Proceedings Paper

Noninvasive estimation of light scattering and hemoglobin concentration in mice cutaneous carcinogenesis through multispectral imaging
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Paper Abstract

Skin cancer is the most common cancer, predominantly found in people with light-skin color. With a view to diagnosing at early stage, we evaluated a new optical method to investigate the alterations in skin morphology and hemodynamics during skin cancer in mice by multispectral imaging system as traditional measures based on gross lesions that appear at the advanced stage when the prognosis is terrible. Here, the use of isosbestic wavelengths of hemoglobin makes it possible to measure hemoglobin concentration irrespective of oxygenation status of hemoglobin. Results illustrate that while there scattering power decreased, hemoglobin concentration increased in the carcinogenic mice. It demonstrated that the proposed system is competent to monitor pathophysiological changes specially scattering power and hemoglobin concentration during cutaneous two-stage chemical carcinogenesis.

Paper Details

Date Published: 24 April 2018
PDF: 3 pages
Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107110W (24 April 2018); doi: 10.1117/12.2317410
Show Author Affiliations
Md. Abdul Wares, Tokyo Univ. of Agriculture and Technology (Japan)
Naoki Tobita, Tokyo Univ. of Agriculture and Technology (Japan)
Izumi Nishidate, Tokyo Univ. of Agriculture and Technology (Japan)
Satoko Kawauchi, National Defense Medical College Research Institute (Japan)
Shunichi Sato, National Defense Medical College Research Institute (Japan)

Published in SPIE Proceedings Vol. 10711:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji; Yuan Luo, Editor(s)

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