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Proceedings Paper

In vivo visualization of dermal collagen fibers in human skin using a photonic-crystal-fiber-coupled, hand-held second-harmonic-generation microscope
Author(s): Yuki Ogura; Kosuke Atsuta; Eiji Hase; Takeo Minamikawa; Takeshi Yasui
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Paper Abstract

Second-harmonic-generation (SHG) microscopy is a powerful tool for in vivo monitoring of collagen fibers in human skin. However, its practical use in the dermatological field is still limited due to the bulky and complicated setup. In this paper, we constructed a photonic-crystal-fiber-coupled, hand-held SHG microscope for in vivo monitoring of collagen fibers in human skin. Fiber delivery of ultrashort pulse light was achieved by a large-mode-area photonic-crystal-fiber whereas the SHG microscopy setup was enclosed into a hand-held probe head. The combination of PCF with the hand-held probe head largely enhances the flexibility of measurement sites in the human skin.

Paper Details

Date Published: 24 April 2018
PDF: 5 pages
Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107111C (24 April 2018); doi: 10.1117/12.2316930
Show Author Affiliations
Yuki Ogura, Tokushima Univ. (Japan)
Kosuke Atsuta, Tokushima Univ. (Japan)
Eiji Hase, Tokushima Univ. (Japan)
JASRI/SPring-8 (Japan)
Takeo Minamikawa, Tokushima Univ. (Japan)
Takeshi Yasui, Tokushima Univ. (Japan)

Published in SPIE Proceedings Vol. 10711:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji; Yuan Luo, Editor(s)

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