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Proceedings Paper

Application of spectroscopic methods for the prevention of side effects on patients during chemotherapy (Conference Presentation)
Author(s): Jürgen Lademann; Maxim E. Darvin; Johannes Schleusener; Gisela Thiede; Thomas Bocklitz; Martina C. Meinke; Sora Jung

Paper Abstract

Although chemotherapeutics for cancer treatment are becoming increasingly efficient these days, they often cause severe dermal side effects. Systemically applied doxorubicin is known for inducing free radicals, which leads to the development of the hand-foot syndrome. This syndrome manifests itself through skin irritations, extending from blistering to open wounds. As doxorubicin exhibits a fluorescence signal in the 520-600 nm region if excited at 488 nm, the doxorubicin’s leakage onto the skin surface could be analyzed. It was found that part of the doxorubicin is ejected with the sweat onto the skin surface, where it spreads and penetrates into the skin like topically applied. By topical application of antioxidants, the doxorubicin could be prevented from inducing free radicals in the skin and consequently the hand-foot syndrome. Raman spectroscopy was used to show that the action mechanism of chemotherapeutics not showing fluorescence signals is similar to the action mechanism of doxorubicin.

Paper Details

Date Published: 15 March 2018
Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930M (15 March 2018); doi: 10.1117/12.2316588
Show Author Affiliations
Jürgen Lademann, Charité Universitätsmedizin Berlin (Germany)
Maxim E. Darvin, Charité Universitätsmedizin Berlin (Germany)
Johannes Schleusener, Charité Universitätsmedizin Berlin (Germany)
Gisela Thiede, Charité Universitätsmedizin Berlin (Germany)
Thomas Bocklitz, Friedrich-Schiller-Univ. (Germany)
Martina C. Meinke, Charité Universitätsmedizin Berlin (Germany)
Sora Jung, Charité Universitätsmedizin Berlin (Germany)

Published in SPIE Proceedings Vol. 10493:
Dynamics and Fluctuations in Biomedical Photonics XV
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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