Share Email Print

Proceedings Paper

Photobiomodulation laser improves the early repair process of hypothyroid rats
Author(s): V. D. Uzêda e Silva; T. T. Rodriguez; F. C. A. Xavier; J. N. dos Santos; R. M. Vasconcelos; L. M. P. Ramalho
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Delay in wound healing has been observed in the hypothyroidism disfunction. Laser light can modulate various biological phenomena acting on different cell types. However, there are few reports in the literature regarding the effects of laser on wound healing of hypothyroid models. This study aimed to evaluate the differences in reepithelialization process of cutaneous wounds on hypothyroid and euthyroid rats treated with laser phototherapy. Forty-eight rats were divided into two main groups: euthyroid (EU) and hypothyroid (HYPO). Hypothyroidism was induced by Thyroidectomy. Each group was divided into subgroups: control (without laser) and laser groups. Standard surgical wound was created on the dorsum of each rat. The irradiation protocols (λ660 nm, 40 mW, CW; 10 J/cm2) was carried out immediately after wounding and repeated every 24h during 3 and 7 days. After animal death, specimens were taken, routinely processed, cut, stained with hematoxylin-eosin, and underwent histological analysis. Three days after the surgery, it was possible to observe initial reepithelialization in more advanced stages in the wound area of the irradiated hypothyroid group when compared to control hypothyroid group (p<0.05). No significant difference was found in the experimental period of 7 days among the groups. It was concluded that the laser light did influence reepithelialization process on hypothyroid rats in early stages of healing process.

Paper Details

Date Published: 16 April 2018
PDF: 5 pages
Proc. SPIE 10582, Laser Florence 2017: Advances in Laser Medicine, 1058206 (16 April 2018); doi: 10.1117/12.2315638
Show Author Affiliations
V. D. Uzêda e Silva, Univ. Federal da Bahia (Brazil)
T. T. Rodriguez, Univ. Federal da Bahia (Brazil)
F. C. A. Xavier, Univ. Federal da Bahia (Brazil)
J. N. dos Santos, Univ. Federal da Bahia (Brazil)
R. M. Vasconcelos, New York Univ. Langone Medical Ctr. (United States)
L. M. P. Ramalho, Univ. Federal da Bahia (Brazil)

Published in SPIE Proceedings Vol. 10582:
Laser Florence 2017: Advances in Laser Medicine
Leonardo Longo, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?