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Proceedings Paper

Low auto-fluorescence broadband antireflection coatings for human genome sequencing optical platform
Author(s): Jing Du; Jue Wang; Horst Schreiber; Jean Francois Oudard
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Paper Abstract

Ever since the human genome was first sequenced, scientists have been inspired by possibilities of using genomic information for medical research. In recent year, new generation sequencing platform to deliver complete genome sequence data with higher throughputs are to be built to conduct genomic studies on a large scale. This requires the development of a wide field multi-channel fluorescence imager system. The complexity of this optical system for human genome sequencing application would also have specific optical coating challenges. For the objective lens system, it requires selection of multiple glass types with normal and anomalous dispersions in order to successfully correct chromatic aberrations to diffraction-limited level over a broad wavelength spectrum. The challenge is anti-reflection (AR) coatings need to be coated over these multi-glass types with various refractive index from 1.43 to 1.8 and operate through an extended range of broad spectrum range. In addition, auto-fluorescence of optical components and coatings applied to the lenses are considered an isotropic generation of the secondary stray light inside the system. This is undesirable and should be minimized. This research work presents the AR coating design strategy to accommodate the multiple glass types in the lens system over a broadband application range and the investigation results of achieving low auto-fluorescence through material selection and coating process control.

Paper Details

Date Published: 8 May 2018
PDF: 7 pages
Proc. SPIE 10627, Advanced Optics for Defense Applications: UV through LWIR III, 106270J (8 May 2018); doi: 10.1117/12.2311319
Show Author Affiliations
Jing Du, Corning Incorporated (United States)
Jue Wang, Corning Incorporated (United States)
Horst Schreiber, Corning Incorporated (United States)
Jean Francois Oudard, Corning Incorporated (United States)

Published in SPIE Proceedings Vol. 10627:
Advanced Optics for Defense Applications: UV through LWIR III
Jay N. Vizgaitis; Bjørn F. Andresen; Peter L. Marasco; Jasbinder S. Sanghera; Miguel P. Snyder, Editor(s)

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